Poor Prognosis of Children With Pre - B Acute Lymphoblastic Leukemia Is
نویسندگان
چکیده
The prognostic significance of chromosomal translocations, particularly t(l;19) (q23;p13), was evaluated in children with pre-B and early pre-B acute lymphoblastic leukemia (ALL). Patients were treated on a risk-based protocol of the Pediatric Oncology Group (POW between February 1986 and May 1989. An abnormal clone was detected in 46% (1 30 of 2851 of pre-B cases and 56% (380 of 679) of early pre-B cases. Translocation of any type was associated with a worse treatment outcome than other karyotypic abnormalities: 15 of 66 versus 3 of 64 failed therapy in the pre-B group (P = ,001 1, and 37 of 141 versus 23 of 239 failed in the early pre-B group ( P cc .001). The t( l :I91 (q23:p13) occurred significantly more often in cases of pre-B ALL with a clonal abnormality than in early pre-B ALL cases (29 of 130 v 5 of 380, P < .001). Among the 285
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